2021年 筑波大学内分泌代謝・糖尿病内科の研究業績を掲載しています。

Takeuchi Y, Yahagi N, Aita Y, Mehrazad-Saber Z, Ho MH, Huyan Y, Murayama Y, Shikama A, Masuda Y, Izumida Y, Miyamoto T, Matsuzaka T, Kawakami Y, Shimano H.

FoxO-KLF15 pathway switches the flow of macronutrients under the control of insulin. iScience. 2021 Nov 15;24(12):103446. doi: 10.1016/j.isci.2021.103446. PMID: 34988390; PMCID: PMC8710527.

Sekiya M, Kainoh K, Sugasawa T, Yoshino R, Hirokawa T, Tokiwa H, Nakano S, Nagatoishi S, Tsumoto K, Takeuchi Y, Miyamoto T, Matsuzaka T, Shimano H.

The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis. Nat Commun. 2021 Nov 2;12(1):6315. doi: 10.1038/s41467-021-26638-5. PMID: 34728642; PMCID: PMC8563733.

Midorikawa M, Suzuki H, Suzuki Y, Yamauchi K, Sato H, Nemoto K, Sugano Y, Iwasaki H, Sekiya M, Yatoh S, Yahagi N, Hada Y, Arai T, Shimano H.

Relationships between Cognitive Function and Odor Identification, Balance Capability, and Muscle Strength in Middle-Aged Persons with and without Type 2 Diabetes. J Diabetes Res. 2021 Oct 7;2021:9961612. doi: 10.1155/2021/9961612. PMID: 34660814; PMCID: PMC8516531.

Nakagawa Y, Araki M, Han SI, Mizunoe Y, Shimano H.

CREBH Systemically Regulates Lipid Metabolism by Modulating and Integrating Cellular Functions. Nutrients. 2021 Sep 15;13(9):3204. doi: 10.3390/nu13093204. PMID: 34579081; PMCID: PMC8472586.

Miyamoto T, Han SI, Shimano H.

Protocol for rapid manipulation of mitochondrial morphology in living cells using inducible counter mitochondrial morphology (iCMM). STAR Protoc. 2021 Aug 5;2(3):100721. doi: 10.1016/j.xpro.2021.100721. PMID: 34401787; PMCID: PMC8353406.

Kainoh K, Takano R, Sekiya M, Saito K, Sugasawa T, Ma Y, Murayama Y, Sugano Y, Osaki Y, Iwasaki H, Takeuchi Y, Yahagi N, Suzuki H, Miyamoto T, Nakagawa Y, Matsuzaka T, Shimano H.

CtBP2 confers protection against oxidative stress through interactions with NRF1 and NRF2. Biochem Biophys Res Commun. 2021 May 27;562:146-153. doi: 10.1016/j.bbrc.2021.05.069. Epub ahead of print. PMID: 34052660.

Nakagawa Y, Kumagai K, Han SI, Mizunoe Y, Araki M, Mizuno S, Ohno H, Matsuo K, Yamada Y, Kim JD, Miyamoto T, Sekiya M, Konishi M, Itoh N, Matsuzaka T, Takahashi S, Sone H, Shimano H.

Starvation-induced transcription factor CREBH negatively governs body growth by controlling GH signaling. FASEB J. 2021 Jun;35(6):e21663. doi: 10.1096/fj.202002784RR. PMID: 34042217.