筑波大学内分泌代謝・糖尿病内科の研究業績を掲載しています。

Okajima Y, Matsuzaka T, Miyazaki S, Motomura K, Ohno H, Sharma R, Shimura T, Istiqamah N, Han SI, Mizunoe Y, Osaki Y, Iwasaki H, Yatoh S, Suzuki H, Sone H, Miyamoto T, Aita Y, Takeuchi Y, Sekiya M, Yahagi N, Nakagawa Y, Tomita T, Shimano H.

Morphological and functional adaptation of pancreatic islet blood vessels to insulin resistance is impaired in diabetic db/db mice. Biochim Biophys Acta Mol Basis Dis. 2022 Jan 8;1868(4):166339. doi: 10.1016/j.bbadis.2022.166339. Epub ahead of print. PMID: 35017029.

Takeuchi Y, Yahagi N, Aita Y, Mehrazad-Saber Z, Ho MH, Huyan Y, Murayama Y, Shikama A, Masuda Y, Izumida Y, Miyamoto T, Matsuzaka T, Kawakami Y, Shimano H.

FoxO-KLF15 pathway switches the flow of macronutrients under the control of insulin. iScience. 2021 Nov 15;24(12):103446. doi: 10.1016/j.isci.2021.103446. PMID: 34988390; PMCID: PMC8710527.

Sekiya M, Kainoh K, Sugasawa T, Yoshino R, Hirokawa T, Tokiwa H, Nakano S, Nagatoishi S, Tsumoto K, Takeuchi Y, Miyamoto T, Matsuzaka T, Shimano H.

The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis. Nat Commun. 2021 Nov 2;12(1):6315. doi: 10.1038/s41467-021-26638-5. PMID: 34728642; PMCID: PMC8563733.

Midorikawa M, Suzuki H, Suzuki Y, Yamauchi K, Sato H, Nemoto K, Sugano Y, Iwasaki H, Sekiya M, Yatoh S, Yahagi N, Hada Y, Arai T, Shimano H.

Relationships between Cognitive Function and Odor Identification, Balance Capability, and Muscle Strength in Middle-Aged Persons with and without Type 2 Diabetes. J Diabetes Res. 2021 Oct 7;2021:9961612. doi: 10.1155/2021/9961612. PMID: 34660814; PMCID: PMC8516531.

Nakagawa Y, Araki M, Han SI, Mizunoe Y, Shimano H.

CREBH Systemically Regulates Lipid Metabolism by Modulating and Integrating Cellular Functions. Nutrients. 2021 Sep 15;13(9):3204. doi: 10.3390/nu13093204. PMID: 34579081; PMCID: PMC8472586.

Miyamoto T, Han SI, Shimano H.

Protocol for rapid manipulation of mitochondrial morphology in living cells using inducible counter mitochondrial morphology (iCMM). STAR Protoc. 2021 Aug 5;2(3):100721. doi: 10.1016/j.xpro.2021.100721. PMID: 34401787; PMCID: PMC8353406.

Kainoh K, Takano R, Sekiya M, Saito K, Sugasawa T, Ma Y, Murayama Y, Sugano Y, Osaki Y, Iwasaki H, Takeuchi Y, Yahagi N, Suzuki H, Miyamoto T, Nakagawa Y, Matsuzaka T, Shimano H.

CtBP2 confers protection against oxidative stress through interactions with NRF1 and NRF2. Biochem Biophys Res Commun. 2021 May 27;562:146-153. doi: 10.1016/j.bbrc.2021.05.069. Epub ahead of print. PMID: 34052660.

Nakagawa Y, Kumagai K, Han SI, Mizunoe Y, Araki M, Mizuno S, Ohno H, Matsuo K, Yamada Y, Kim JD, Miyamoto T, Sekiya M, Konishi M, Itoh N, Matsuzaka T, Takahashi S, Sone H, Shimano H.

Starvation-induced transcription factor CREBH negatively governs body growth by controlling GH signaling. FASEB J. 2021 Jun;35(6):e21663. doi: 10.1096/fj.202002784RR. PMID: 34042217.

Nakagawa Y, Wang Y, Han SI, Okuda K, Oishi A, Yagishita Y, Kumagai K, Ohno H, Osaki Y, Mizunoe Y, Araki M, Murayama Y, Iwasaki H, Konishi M, Itoh N, Matsuzaka T, Sone H, Yamada N, Shimano H.

Enterohepatic Transcription Factor CREB3L3 Protects Atherosclerosis via SREBP Competitive Inhibition. Cell Mol Gastroenterol Hepatol. 2021;11(4):949-971. doi: 10.1016/j.jcmgh.2020.11.004. Epub 2020 Nov 24. PMID: 33246135; PMCID: PMC7900604.

Sekiya M, Matsuda T, Yamamoto Y, Furuta Y, Ohyama M, Murayama Y, Sugano Y, Ohsaki Y, Iwasaki H, Yahagi N, Yatoh S, Suzuki H, Shimano H.

Deciphering genetic signatures by whole exome sequencing in a case of co-prevalence of severe renal hypouricemia and diabetes with impaired insulin secretion. BMC Med Genet. 2020 May 6;21(1):91. doi: 10.1186/s12881-020-01031-z. PMID: 32375679; PMCID: PMC7201978.

Matsuzaka T, Shimano H.

New perspective on type 2 diabetes, dyslipidemia and non-alcoholic fatty liver disease. J Diabetes Investig. 2020 May;11(3):532-534. doi: 10.1111/jdi.13258. Epub 2020 May 12. PMID: 32232972; PMCID: PMC7232277.

Satoh A, Han SI, Araki M, Nakagawa Y, Ohno H, Mizunoe Y, Kumagai K, Murayama Y, Osaki Y, Iwasaki H, Sekiya M, Konishi M, Itoh N, Matsuzaka T, Sone H, Shimano H.

CREBH Improves Diet-Induced Obesity, Insulin Resistance, and Metabolic Disturbances by FGF21-Dependent and FGF21-Independent Mechanisms. iScience. 2020 Mar 27;23(3):100930. doi: 10.1016/j.isci.2020.100930. Epub 2020 Feb 21. PMID: 32151974; PMCID: PMC7063134.

Ma Y, Sekiya M, Kainoh K, Matsuda T, Iwasaki H, Osaki Y, Sugano Y, Suzuki H, Takeuchi Y, Miyamoto T, Yahagi N, Nakagawa Y, Matsuzaka T, Shimano H.

Transcriptional co-repressor CtBP2 orchestrates epithelial-mesenchymal transition through a novel transcriptional holocomplex with OCT1. Biochem Biophys Res Commun. 2020 Mar 5;523(2):354-360. doi: 10.1016/j.bbrc.2019.12.070. Epub 2019 Dec 19. PMID: 31866012.

Matsuzaka T, Kuba M, Koyasu S, Yamamoto Y, Motomura K, Arulmozhiraja S, Ohno H, Sharma R, Shimura T, Okajima Y, Han SI, Aita Y, Mizunoe Y, Osaki Y, Iwasaki H, Yatoh S, Suzuki H, Sone H, Takeuchi Y, Yahagi N, Miyamoto T, Sekiya M, Nakagawa Y, Ema M, Takahashi S, Tokiwa H, Shimano H.

Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice. Hepatology. 2020 May;71(5):1609-1625. doi: 10.1002/hep.30953. Epub 2020 Feb 7. PMID: 31529722.

Miyamoto T, Matsuzaka T, Shimano H.

Rho-associated, coiled-coil-containing protein kinase 1 as a new player in the regulation of hepatic lipogenesis. J Diabetes Investig. 2019 Sep;10(5):1165-1167. doi: 10.1111/jdi.13051. Epub 2019 Apr 19. PMID: 30919598; PMCID: PMC6717821.