12月21日 L.X

Loss of Egr-1 sensitizes pancreatic β-cells to palmitate-induced ER stress and apoptosis. 

Cheong MW, Kuo LH, Cheng YN, Tsai PJ, Ho LC, Tai HC, Chiu WT, Chen SH, Lu PJ, Shan YS, Chuang LM, Tsai YS. 

J Mol Med (Berl). 2015 Jul;93(7):807-18.

12月10日 Y.K

Microbiota depletion promotes browning of white adipose tissue and reduces obesity.

Suárez-Zamorano N, Fabbiano S, Chevalier C, Stojanović O, Colin DJ, Stevanović A, Veyrat-Durebex C, Tarallo V, Rigo D, Germain S, Ilievska M, Montet X, Seimbille Y, Hapfelmeier S, Trajkovski M.

Nat Med. 2015 Dec;21(12):1497-501. 

12月3日 M.K

Intracellular activation of EGFR by fatty acid synthase dependent palmitoylation.

Bollu LR, Katreddy RR, Blessing AM, Pham N, Zheng B, Wu X, Weihua Z.

Oncotarget. 2015 Oct 27;6(33):34992-5003. 

11月30日 Y.Y

Lysine Acetylation of CREBH Regulates Fasting-Induced Hepatic Lipid Metabolism.

Kim H, Mendez R, Chen X, Fang D, Zhang K.

Mol Cell Biol. 2015 Dec 15;35(24):4121-34. 

11月25日 T.K

A Diet-Sensitive BAF60a-Mediated Pathway Links Hepatic Bile Acid Metabolism to Cholesterol Absorption and Atherosclerosis.

Meng ZX, Wang L, Chang L, Sun J, Bao J, Li Y, Chen YE, Lin JD.

Cell Rep. 2015 Nov 24;13(8):1658-69. 

11月16日 Y.M

Cold Exposure Partially Corrects Disturbances in Lipid Metabolism in a Male Mouse Model of Glucocorticoid Excess.

van den Beukel JC, Boon MR, Steenbergen J, Rensen PC, Meijer OC, Themmen AP, Grefhorst A.

Endocrinology. 2015 Nov;156(11):4115-28.


FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.

Claussnitzer M, Dankel SN, Kim KH, Quon G, Meuleman W, Haugen C, Glunk V, Sousa IS, Beaudry JL, Puviindran V, Abdennur NA, Liu J, Svensson PA, Hsu YH, Drucker DJ, Mellgren G, Hui CC, Hauner H, Kellis M.

N Engl J Med. 2015 Sep 3;373(10):895-907. 

11月2日 N.T

Nighttime Administration of Nicotine Improves Hepatic Glucose Metabolism via the Hypothalamic Orexin System in Mice.

Tsuneki H, Nagata T, Fujita M, Kon K, Wu N, Takatsuki M, Yamaguchi K, Wada T, Nishijo H, Yanagisawa M, Sakurai T, Sasaoka T.

Endocrinology. 2015 Oct 22:en20151488. 

10月29日 Y.O

Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle.

Kubota T, Kubota N, Kumagai H, Yamaguchi S, Kozono H, Takahashi T, Inoue M, Itoh S, Takamoto I, Sasako T, Kumagai K, Kawai T, Hashimoto S, Kobayashi T, Sato M, Tokuyama K, Nishimura S, Tsunoda M, Ide T, Murakami K, Yamazaki T, Ezaki O, Kawamura K, Masuda H, Moroi M, Sugi K, Oike Y, Shimokawa H, Yanagihara N, Tsutsui M, Terauchi Y, Tobe K, Nagai R, Kamata K, Inoue K, Kodama T, Ueki K, Kadowaki T.

Cell Metab. 2011 Mar 2;13(3):294-307. 

10月8日 Y.Y

PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus.

Xu D, Wang Z, Zhang Y, Jiang W, Pan Y, Song BL, Chen Y.

Nat Commun. 2015 Aug 27;6:8100.

10月1日 H.O

MiR-93 Controls Adiposity via Inhibition of Sirt7 and Tbx3.

Cioffi M, Vallespinos-Serrano M, Trabulo SM, Fernandez-Marcos PJ, Firment AN, Vazquez BN, Vieira CR, Mulero F, Camara JA, Cronin UP, Perez M, Soriano J, G Galvez B, Castells-Garcia A, Haage V, Raj D, Megias D, Hahn S, Serrano L, Moon A, Aicher A, Heeschen C.

Cell Rep. 2015 Sep 8;12(10):1594-605. 

8月10日 Y.S

Metabolism. Differential regulation of mTORC1 by leucine and glutamine.

Jewell JL, Kim YC, Russell RC, Yu FX, Park HW, Plouffe SW, Tagliabracci VS, Guan KL.

Science. 2015 Jan 9;347(6218):194-8. 

8月6日 P.XY

Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes.

Pang DX, Smith AJ, Humphries SE.

Nutr Metab Cardiovasc Dis. 2013 Jun;23(6):550-6.

7月27日 Y.K

Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter.

Wang J, Sun C, Gerdes N, Liu C, Liao M, Liu J, Shi MA, He A, Zhou Y, Sukhova GK, Chen H, Cheng XW, Kuzuya M, Murohara T, Zhang J, Cheng X, Jiang M, Shull GE, Rogers S, Yang CL, Ke Q, Jelen S, Bindels R, Ellison DH, Jarolim P, Libby P, Shi GP.

Nat Med. 2015 Jul;21(7):820-6.

7月13日 Y.Y

Activation of hepatic CREBH and Insig signaling in the anti-hypertriglyceridemic mechanism of R-α-lipoic acid.

Tong X, Christian P, Zhao M, Wang H, Moreau R, Su Q.

J Nutr Biochem. 2015 Sep;26(9):921-8. 

7月6日 M.K

Diet-induced obese mice retain endogenous leptin action.

Ottaway N, Mahbod P, Rivero B, Norman LA, Gertler A, D'Alessio DA, Perez-Tilve D.

Cell Metab. 2015 Jun 2;21(6):877-82.

7月2日 N.T

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan.

Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD.

Cell Metab. 2015 Jul 7;22(1):86-99. 

6月22日 Y.O

Insulin receptor substrate-2 (Irs2) in endothelial cells plays a crucial role in insulin secretion.

Hashimoto S, Kubota N, Sato H, Sasaki M, Takamoto I, Kubota T, Nakaya K, Noda M, Ueki K, Kadowaki T.

Diabetes. 2015 Mar;64(3):876-86. 

6月15日 N.T

Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell-Driven Condensation.

Takebe T, Enomura M, Yoshizawa E, Kimura M, Koike H, Ueno Y, Matsuzaki T, Yamazaki T, Toyohara T, Osafune K, Nakauchi H, Yoshikawa HY, Taniguchi H.

Cell Stem Cell. 2015 May 7;16(5):556-65. 

6月11日 K.T

Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia.

Jha P, Claudel T, Baghdasaryan A, Mueller M, Halilbasic E, Das SK, Lass A, Zimmermann R, Zechner R, Hoefler G, Trauner M.

Hepatology. 2014 Mar;59(3):858-69. 

6月8日 H.O

Central serotonergic neurons activate and recruit thermogenic brown and beige fat and regulate glucose and lipid homeostasis.

McGlashon JM, Gorecki MC, Kozlowski AE, Thirnbeck CK, Markan KR, Leslie KL, Kotas ME, Potthoff MJ, Richerson GB, Gillum MP.

Cell Metab. 2015 May 5;21(5):692-705. 

5月28日 Y.S

L-cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2.

Nakatsu D, Horiuchi Y, Kano F, Noguchi Y, Sugawara T, Takamoto I, Kubota N, Kadowaki T, Murata M.

Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):E1067-76. 

5月18日 F.O

Ascl2 acts as an R-spondin/Wnt-responsive switch to control stemness in intestinal crypts.

Schuijers J, Junker JP, Mokry M, Hatzis P, Koo BK, Sasselli V, van der Flier LG, Cuppen E, van Oudenaarden A, Clevers H.

Cell Stem Cell. 2015 Feb 5;16(2):158-70. 

5月14日 M.K

Pharmacologic Effects of FGF21 Are Independent of the "Browning" of White Adipose Tissue.

Véniant MM, Sivits G, Helmering J, Komorowski R, Lee J, Fan W, Moyer C, Lloyd DJ.

Cell Metab. 2015 May 5;21(5):731-8.

5月11日 T.K

Regulation of obesity-related insulin resistance with gut anti-inflammatory agents.

Luck H, Tsai S, Chung J, Clemente-Casares X, Ghazarian M, Revelo XS, Lei H, Luk CT, Shi SY, Surendra A, Copeland JK, Ahn J, Prescott D, Rasmussen BA, Chng MH, Engleman EG, Girardin SE, Lam TK, Croitoru K, Dunn S, Philpott DJ, Guttman DS, Woo M, Winer S, Winer DA.

Cell Metab. 2015 Apr 7;21(4):527-42. 

5月7日 Y.K

Oral supplementation with non-absorbable antibiotics or curcumin attenuates western diet-induced atherosclerosis and glucose intolerance in LDLR-/- mice--role of intestinal permeability and macrophage activation.

Ghosh SS, Bie J, Wang J, Ghosh S.

PLoS One. 2014 Sep 24;9(9):e108577. 

4月23日 T.K

LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes.

Li P, Oh da Y, Bandyopadhyay G, Lagakos WS, Talukdar S, Osborn O, Johnson A, Chung H, Mayoral R, Maris M, Ofrecio JM, Taguchi S, Lu M, Olefsky JM.

Nat Med. 2015 Mar;21(3):239-47.

4月16日 Y.O

Islet hyperperfusion during prediabetic phase in OLETF rats, a model of type 2 diabetes.

Iwase M, Uchizono Y, Tashiro K, Goto D, Iida M.

Diabetes. 2002 Aug;51(8):2530-5.

4月9日 H.O

An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ.

Banks AS, McAllister FE, Camporez JP, Zushin PJ, Jurczak MJ, Laznik-Bogoslavski D, Shulman GI, Gygi SP, Spiegelman BM.

Nature. 2015 Jan 15;517(7534):391-5.

4月6日 A.S

A liver-enriched long non-coding RNA, lncLSTR, regulates systemic lipid metabolism in mice.

Li P, Ruan X, Yang L, Kiesewetter K, Zhao Y, Luo H, Chen Y, Gucek M, Zhu J, Cao H.

Cell Metab. 2015 Mar 3;21(3):455-67. 

3月9日 Y.K

Diet and feeding pattern affect the diurnal dynamics of the gut microbiome.

Zarrinpar A, Chaix A, Yooseph S, Panda S.

Cell Metab. 2014 Dec 2;20(6):1006-17.

3月2日 M.K

Time-restricted feeding is a preventative and therapeutic intervention against diverse nutritional challenges.

Chaix A, Zarrinpar A, Miu P, Panda S.

Cell Metab. 2014 Dec 2;20(6):991-1005.

2月19日 P.XY

Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex.

Konermann S, Brigham MD, Trevino AE, Joung J, Abudayyeh OO, Barcena C, Hsu PD, Habib N, Gootenberg JS, Nishimasu H, Nureki O, Zhang F.

Nature. 2015 Jan 29;517(7536):583-8.

2月16日 Y.O

Cellular hypoxia of pancreatic beta-cells due to high levels of oxygen consumption for insulin secretion in vitro.

Sato Y, Endo H, Okuyama H, Takeda T, Iwahashi H, Imagawa A, Yamagata K, Shimomura I, Inoue M.

J Biol Chem. 2011 Apr 8;286(14):12524-32.

2月2日 Y.O

Shear-stress-mediated refolding of proteins from aggregates and inclusion bodies.

Yuan TZ, Ormonde CF, Kudlacek ST, Kunche S, Smith JN, Brown WA, Pugliese KM, Olsen TJ, Iftikhar M, Raston CL, Weiss GA.

Chembiochem. 2015 Feb 9;16(3):393-6. 

1月29日 N.T

Innate immunity. Dermal adipocytes protect against invasive Staphylococcus aureus skin infection.

Zhang LJ, Guerrero-Juarez CF, Hata T, Bapat SP, Ramos R, Plikus MV, Gallo RL.

Science. 2015 Jan 2;347(6217):67-71. 

1月22日 H.Z

In vivo pancreatic β-cell-specific expression of antiaging gene Klotho: a novel approach for preserving β-cells in type 2 diabetes.

Lin Y, Sun Z.

Diabetes. 2015 Apr;64(4):1444-58.

1月20日 H.O

MicroRNA-33 regulates sterol regulatory element-binding protein 1 expression in mice.

Horie T, Nishino T, Baba O, Kuwabara Y, Nakao T, Nishiga M, Usami S, Izuhara M, Sowa N, Yahagi N, Shimano H, Matsumura S, Inoue K, Marusawa H, Nakamura T, Hasegawa K, Kume N, Yokode M, Kita T, Kimura T, Ono K.

Nat Commun. 2013;4:2883.


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