2014年

12月22日 Y.O

Impaired proteolysis underlies autophagic dysfunction in Niemann-Pick type C disease.

Elrick MJ, Yu T, Chung C, Lieberman AP.

Hum Mol Genet. 2012 Nov 15;21(22):4876-87. 


12月11日 Y.S

The Arachidonic Acid Metabolome Serves as a Conserved Regulator of Cholesterol Metabolism.

Demetz E, Schroll A, Auer K, Heim C, Patsch JR, Eller P, Theurl M, Theurl I, Theurl M, Seifert M, Lener D, Stanzl U, Haschka D, Asshoff M, Dichtl S, Nairz M, Huber E, Stadlinger M, Moschen AR, Li X, Pallweber P, Scharnagl H, Stojakovic T, März W, Kleber ME, Garlaschelli K, Uboldi P, Catapano AL, Stellaard F, Rudling M, Kuba K, Imai Y, Arita M, Schuetz JD, Pramstaller PP, Tietge UJ, Trauner M, Norata GD, Claudel T, Hicks AA, Weiss G, Tancevski I.

Cell Metab. 2014 Oct 16;20(5):787-798. 


12月4日 Y.K

An abundant dysfunctional apolipoprotein A1 in human atheroma.

Huang Y, DiDonato JA, Levison BS, Schmitt D, Li L, Wu Y, Buffa J, Kim T, Gerstenecker GS, Gu X, Kadiyala CS, Wang Z, Culley MK, Hazen JE, Didonato AJ, Fu X, Berisha SZ, Peng D, Nguyen TT, Liang S, Chuang CC, Cho L, Plow EF, Fox PL, Gogonea V, Tang WH, Parks JS, Fisher EA, Smith JD, Hazen SL.

Nat Med. 2014 Feb;20(2):193-203. 


11月19日 A.S

Nutrient-sensing nuclear receptors coordinate autophagy.

Lee JM, Wagner M, Xiao R, Kim KH, Feng D, Lazar MA, Moore DD.

Nature. 2014 Dec 4;516(7529):112-5.


11月13日 M.K

Osteocalcin protects against non-alcoholic steatohepatitis in a mouse model of metabolic syndrome.

Gupte AA, Sabek OM, Fraga D, Minze LJ, Nishimoto SK, Liu JZ, Afshar S, Gaber L, Lyon CJ, Osama Gaber A, Hsueh WA.

Endocrinology. 2014 Oct 3:en20141430.


10月20日 N.T

Generation of functional human pancreatic β cells in vitro.

Pagliuca FW, Millman JR, Gürtler M, Segel M, Van Dervort A, Ryu JH, Peterson QP, Greiner D, Melton DA.

Cell. 2014 Oct 9;159(2):428-39. 


10月9日 H.O

Obesity- and aging-induced excess of central transforming growth factor-β potentiates diabetic development via an RNA stress response.

Yan J, Zhang H, Yin Y, Li J, Tang Y, Purkayastha S, Li L, Cai D.

Nat Med. 2014 Sep;20(9):1001-8. 


10月8日 O.Y

Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression.

Agudelo LZ, Femenía T, Orhan F, Porsmyr-Palmertz M, Goiny M, Martinez-Redondo V, Correia JC, Izadi M, Bhat M, Schuppe-Koistinen I, Pettersson AT, Ferreira DM, Krook A, Barres R, Zierath JR, Erhardt S, Lindskog M, Ruas JL.

Cell. 2014 Sep 25;159(1):33-45. 


10月6日 Y.F

Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes.

Fuente-Martín E, García-Cáceres C, Granado M, de Ceballos ML, Sánchez-Garrido MÁ, Sarman B, Liu ZW, Dietrich MO, Tena-Sempere M, Argente-Arizón P, Díaz F, Argente J, Horvath TL, Chowen JA.

J Clin Invest. 2012 Nov 1;122(11):3900-13. 


10月2日 Y.O

Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A.

Lu Y, Dong S, Hao B, Li C, Zhu K, Guo W, Wang Q, Cheung KH, Wong CW, Wu WT, Markus H, Yue J.

Autophagy. 2014 Nov 2;10(11):1895-905. 


9月11日 F.O

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease.

Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, Nieuwenhuis EE, Higgins DE, Schreiber S, Glimcher LH, Blumberg RS.

Cell. 2008 Sep 5;134(5):743-56. 


9月8日 K.T

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes.

Marcheva B, Ramsey KM, Buhr ED, Kobayashi Y, Su H, Ko CH, Ivanova G, Omura C, Mo S, Vitaterna MH, Lopez JP, Philipson LH, Bradfield CA, Crosby SD, JeBailey L, Wang X, Takahashi JS, Bass J.

Nature. 2010 Jul 29;466(7306):627-31. 


9月1日 M.K

Osteocytes regulate primary lymphoid organs and fat metabolism.

Sato M, Asada N, Kawano Y, Wakahashi K, Minagawa K, Kawano H, Sada A, Ikeda K, Matsui T, Katayama Y.

Cell Metab. 2013 Nov 5;18(5):749-58.


8月19日 E.Y

Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity.

Bi P, Shan T, Liu W, Yue F, Yang X, Liang XR, Wang J, Li J, Carlesso N, Liu X, Kuang S.

Nat Med. 2014 Aug;20(8):911-8. 


8月18日 Y.K

An orally administered redox nanoparticle that accumulates in the colonic mucosa and reduces colitis in mice.

Vong LB, Tomita T, Yoshitomi T, Matsui H, Nagasaki Y.

Gastroenterology. 2012 Oct;143(4):1027-36.e3. 


7月17日 Y.F

Adipsin is an adipokine that improves β cell function in diabetes.

Lo JC, Ljubicic S, Leibiger B, Kern M, Leibiger IB, Moede T, Kelly ME, Chatterjee Bhowmick D, Murano I, Cohen P, Banks AS, Khandekar MJ, Dietrich A, Flier JS, Cinti S, Blüher M, Danial NN, Berggren PO, Spiegelman BM.

Cell. 2014 Jul 3;158(1):41-53. 


7月7日 Y.O

Islet microenvironment, modulated by vascular endothelial growth factor-A signaling, promotes β cell regeneration.

Brissova M, Aamodt K, Brahmachary P, Prasad N, Hong JY, Dai C, Mellati M, Shostak A, Poffenberger G, Aramandla R, Levy SE, Powers AC.

Cell Metab. 2014 Mar 4;19(3):498-511.


6月23日 H.O

Macrophage Elovl6 deficiency ameliorates foam cell formation and reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.

Saito R, Matsuzaka T, Karasawa T, Sekiya M, Okada N, Igarashi M, Matsumori R, Ishii K, Nakagawa Y, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Sone H, Suzuki H, Yahagi N, Yamada N, Shimano H.

Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):1973-9. 


6月19日 N.T

Oxytocin is an age-specific circulating hormone that is necessary for muscle maintenance and regeneration.

Elabd C, Cousin W, Upadhyayula P, Chen RY, Chooljian MS, Li J, Kung S, Jiang KP, Conboy IM.

Nat Commun. 2014 Jun 10;5:4082. 


6月12日 H.Z

PDX1 in ducts is not required for postnatal formation of β-cells but is necessary for their subsequent maturation.

Guo L, Inada A, Aguayo-Mazzucato C, Hollister-Lock J, Fujitani Y, Weir GC, Wright CV, Sharma A, Bonner-Weir S.

Diabetes. 2013 Oct;62(10):3459-68.


6月5日 A.S

FXR is a molecular target for the effects of vertical sleeve gastrectomy.

Ryan KK, Tremaroli V, Clemmensen C, Kovatcheva-Datchary P, Myronovych A, Karns R, Wilson-Pérez HE, Sandoval DA, Kohli R, Bäckhed F, Seeley RJ.

Nature. 2014 May 8;509(7499):183-8.


5月21日 A.S

Glucagon regulates hepatic kisspeptin to impair insulin secretion.

Song WJ, Mondal P, Wolfe A, Alonso LC, Stamateris R, Ong BW, Lim OC, Yang KS, Radovick S, Novaira HJ, Farber EA, Farber CR, Turner SD, Hussain MA.

Cell Metab. 2014 Apr 1;19(4):667-81. 


5月15日 M.K

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone.

Ramasamy SK, Kusumbe AP, Wang L, Adams RH.

Nature. 2014 Mar 20;507(7492):376-80.


5月8日 Y.O

Whole-brain imaging with single-cell resolution using chemical cocktails and computational analysis.

Susaki EA, Tainaka K, Perrin D, Kishino F, Tawara T, Watanabe TM, Yokoyama C, Onoe H, Eguchi M, Yamaguchi S, Abe T, Kiyonari H, Shimizu Y, Miyawaki A, Yokota H, Ueda HR.

Cell. 2014 Apr 24;157(3):726-39. 


5月1日 H.O

Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity.

Ramkhelawon B, Hennessy EJ, Ménager M, Ray TD, Sheedy FJ, Hutchison S, Wanschel A, Oldebeken S, Geoffrion M, Spiro W, Miller G, McPherson R, Rayner KJ, Moore KJ.

Nat Med. 2014 Apr;20(4):377-84.


4月24日 Y.O

BMP signaling controls muscle mass.

Sartori R, Schirwis E, Blaauw B, Bortolanza S, Zhao J, Enzo E, Stantzou A, Mouisel E, Toniolo L, Ferry A, Stricker S, Goldberg AL, Dupont S, Piccolo S, Amthor H, Sandri M.

Nat Genet. 2013 Nov;45(11):1309-18.


4月21日 N.T

Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin.

Fujikawa T, Berglund ED, Patel VR, Ramadori G, Vianna CR, Vong L, Thorel F, Chera S, Herrera PL, Lowell BB, Elmquist JK, Baldi P, Coppari R.

Cell Metab. 2013 Sep 3;18(3):431-44. 


4月17日 F.O

RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis.

Lapierre M, Bonnet S, Bascoul-Mollevi C, Ait-Arsa I, Jalaguier S, Del Rio M, Plateroti M, Roepman P, Ychou M, Pannequin J, Hollande F, Parker M, Cavailles V.

J Clin Invest. 2014 Mar 25. pii: 65178.



4月7日 H.Z

Fatty acid-induced oxidation and triglyceride formation is higher in insulin-producing MIN6 cellsexposed to oleate compared to palmitate.

Thörn K, Bergsten P.

J Cell Biochem. 2010 Oct 1;111(2):497-507.


3月31日 M.K

Altered bone development and turnover in transgenic mice over-expressing lipocalin-2 in bone.

Costa D, Lazzarini E, Canciani B, Giuliani A, Spanò R, Marozzi K, Manescu A, Cancedda R, Tavella S.

J Cell Physiol. 2013 Nov;228(11):2210-21. 


3月24日 T.K

Intestine-Specific Deletion of SIRT1 in Mice Impairs DCoH2-HNF-1α-FXR Signaling and Alters Systemic Bile Acid Homeostasis.

Kazgan N, Metukuri MR, Purushotham A, Lu J, Rao A, Lee S, Pratt-Hyatt M, Lickteig A, Csanaky IL, Zhao Y, Dawson PA, Li X.

Gastroenterology. 2014 Apr;146(4):1006-16. 


3月17日 H.O

Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance.

Beaven SW, Matveyenko A, Wroblewski K, Chao L, Wilpitz D, Hsu TW, Lentz J, Drew B, Hevener AL, Tontonoz P.

Cell Metab. 2013 Jul 2;18(1):106-17. 


2月27日 H.Z

RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function.

Lee JY, Ristow M, Lin X, White MF, Magnuson MA, Hennighausen L.

J Biol Chem. 2006 Feb 3;281(5):2649-53.


26日 S.A

Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation.

Amano SU, Cohen JL, Vangala P, Tencerova M, Nicoloro SM, Yawe JC, Shen Y, Czech MP, Aouadi M.

Cell Metab. 2014 Jan 7;19(1):162-71. 


130日  N.K

Regulation of Steatohepatitis and PPARγ Signaling by Distinct AP-1 Dimers.

Hasenfuss SC, Bakiri L, Thomsen MK, Williams EG, Auwerx J, Wagner EF.

Cell Metab. 2014 Jan 7;19(1):84-95.


123 T.K

The clathrin adaptor Numb regulates intestinal cholesterol absorption through dynamic interactionwith NPC1L1.

Li PS, Fu ZY, Zhang YY, Zhang JH, Xu CQ, Ma YT, Li BL, Song BL.

Nat Med. 2014 Jan;20(1):80-6. 


120日 K.O

Intestinal specific LXR activation stimulates reverse cholesterol transport and protects fromatherosclerosis.

Lo Sasso G, Murzilli S, Salvatore L, D'Errico I, Petruzzelli M, Conca P, Jiang ZY, Calabresi L, Parini P, Moschetta A.

Cell Metab. 2010 Aug 4;12(2):187-93.


1月9日 H.O

Osteocytes regulate primary lymphoid organs and fat metabolism.

Sato M, Asada N, Kawano Y, Wakahashi K, Minagawa K, Kawano H, Sada A, Ikeda K, Matsui T, Katayama Y.

Cell Metab. 2013 Nov 5;18(5):749-58.


関連ファイル

  •  1222 Y.O.doc (35KB)   1222 Y.O
    Hum Mol Genet. 2012 Nov 15;21(22):4876-87.
  •  1020 N.T.docx (17KB)   1020 N.T
    Cell. 2014 Oct 9;159(2):428-39.
  •  1008 O.Y.docx (24KB)   1008 O.Y
    Cell. 2014 Sep 25;159(1):33-45.
  •  1002 Y.O.doc (34KB)   1002 Y.O
    Autophagy. 2014 Nov 2;10(11):1895-905.
  •  0619 N.T.docx (21KB)   0619 N.T
    Nat Commun. 2014 Jun 10;5:4082.
  •  0508 O.Y.docx (20KB)   0508 O.Y
    Cell. 2014 Apr 24;157(3):726-39.
  •  1204 Y.K.docx (16KB)   1204 Y.K
    Nat Med. 2014 Feb;20(2):193-203.
  •  0818 Y.K.docx (16KB)   0818 Y.K
    Gastroenterology. 2012 Oct;143(4):1027-36.e3.
  •  1211 Y.S.docx (20KB)   1211 Y.S
    Cell Metab. 2014 Oct 16;20(5):787-798.
  •  1119 A.S.docx (22KB)   1119 A.S
    Nature. 2014 Dec 4;516(7529):112-5.
  •  1113 M.K.docx (14KB)   1113 M.K
    Endocrinology. 2014 Oct 3:en20141430.
  •  1006 Y.F.docx (17KB)   1006 Y.F
    J Clin Invest. 2012 Nov 1;122(11):3900-13.
  •  1009 H.O.docx (18KB)   1009 H.O
    Nat Med. 2014 Sep;20(9):1001-8.
  •  0819 E.Y.docx (15KB)   0819 E.Y
    Nat Med. 2014 Aug;20(8):911-8.
  •  0717 Y.F.docx (17KB)   0717 Y.F
    Cell. 2014 Jul 3;158(1):41-53.
  •  0908 K.T.docx (21KB)   0908 K.T
    Nature. 2010 Jul 29;466(7306):627-31.
  •  0911 F.O.docx (18KB)   0911 F.O
    Cell. 2008 Sep 5;134(5):743-56.
  •  0901 M.K.docx (16KB)   0901 M.K
    Cell Metab. 2013 Nov 5;18(5):749-58.
  •  0707 Y.O.docx (18KB)   0707 Y.O
    Cell Metab. 2014 Mar 4;19(3):498-511.
  •  0623 H.O.docx (15KB)   0623 H.O
    Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):1973-9.
  •  0612 H.Z.docx (22KB)   0621 H.Z
    Diabetes. 2013 Oct;62(10):3459-68.
  •  0605 A.S.docx (20KB)   0605 A.S
    Nature. 2014 May 8;509(7499):183-8.
  •  0521 A.S.docx (25KB)   0521 A.S
    Cell Metab. 2014 Apr 1;19(4):667-81.
  •  0515 M.K.docx (14KB)   0515 M.K
    Nature. 2014 Mar 20;507(7492):376-80.
  •  0421 N.T.docx (20KB)   0421 N.T
    Cell Metab. 2013 Sep 3;18(3):431-44.
  •  0424_Y.O.doc (29KB)   0424 Y.O
    Nat Genet. 2013 Nov;45(11):1309-18.
  •  0501 H.O.docx (18KB)   0501 H.O
    Nat Med. 2014 Apr;20(4):377-84.
  •  0417 F.O.docx (16KB)   0417 F.O
    J Clin Invest. 2014 Mar 25. pii: 65178.
  •  0407 H.Z.docx (21KB)   0407 H.Z
    J Cell Biochem. 2010 Oct 1;111(2):497-507.
  •  0331 M.K.docx (15KB)   0331 M.K
    J Cell Physiol. 2013 Nov;228(11):2210-21.
  •  0227 H.Z.docx (18KB)   0227 H.Z
    J Biol Chem. 2006 Feb 3;281(5):2649-53.
  •  0317 H.O.docx (16KB)   0317 H.O
    Cell Metab. 2013 Jul 2;18(1):106-17.
  •  0324 T.K..docx (20KB)   0324 T.K
    Gastroenterology. 2014 Apr;146(4):1006-16.
  •  0123 T.K..docx (23KB)   0123 T.K
    Nat Med. 2014 Jan;20(1):80-6.
  •  0206 A.S.docx (22KB)   0206 A.S
    Cell Metab. 2014 Jan 7;19(1):162-71.
  •  0130 N.K.docx (18KB)   0130 N.K
    Cell Metab. 2014 Jan 7;19(1):84-95.
  •  0120.docx (21KB)   0120 K.O
    Cell Metab. 2010 Aug 4;12(2):187-93.
  •  0109 H.O.docx (16KB)   0109 H.O
    Cell Metab. 2013 Nov 5;18(5):749-58.