2013年

12月26日 Y.O

CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes.

Gilbert LA, Larson MH, Morsut L, Liu Z, Brar GA, Torres SE, Stern-Ginossar N, Brandman O, Whitehead EH, Doudna JA, Lim WA, Weissman JS, Qi LS.

Cell. 2013 Jul 18;154(2):442-51.


12月19日 K.O

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.

Fullerton MD, Galic S, Marcinko K, Sikkema S, Pulinilkunnil T, Chen ZP, O'Neill HM, Ford RJ, Palanivel R, O'Brien M, Hardie DG, Macaulay SL, Schertzer JD, Dyck JR, van Denderen BJ, Kemp BE, Steinberg GR.

Nat Med. 2013 Dec;19(12):1649-54.


12月9日 Y.H

Glucose regulates hypothalamic long-chain fatty acid metabolism via AMP-activated Kinase (AMPK) in neurons and astrocytes.

Taib B, Bouyakdan K, Hryhorczuk C, Rodaros D, Fulton S, Alquier T.

J Biol Chem. 2013 Nov 15. 


11月28日 K.I

Rheb regulates mitophagy induced by mitochondrial energetic status.

Melser S, Chatelain EH, Lavie J, Mahfouf W, Jose C, Obre E, Goorden S, Priault M, Elgersma Y, Rezvani HR, Rossignol R, Bénard G.

Cell Metab. 2013 May 7;17(5):719-30. 


11月21日 E.Y

Maternal and offspring pools of osteocalcin influence brain development and functions.

Oury F, Khrimian L, Denny CA, Gardin A, Chamouni A, Goeden N, Huang YY, Lee H, Srinivas P, Gao XB, Suyama S, Langer T, Mann JJ, Horvath TL, Bonnin A, Karsenty G.

Cell. 2013 Sep 26;155(1):228-41.


11月18日 F.O

A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity.

Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami KI, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T.

Nature. 2013 Oct 30.


10月21日 E.Y

Astrocyte-derived ATP modulates depressive-like behaviors.

Cao X, Li LP, Wang Q, Wu Q, Hu HH, Zhang M, Fang YY, Zhang J, Li SJ, Xiong WC, Yan HC, Gao YB, Liu JH, Li XW, Sun LR, Zeng YN, Zhu XH, Gao TM.

Nat Med. 2013 Jun;19(6):773-7. 


10月17日 K.T

Sterol regulatory element-binding protein-1c mediates increase of postprandial stearic acid, a potential target for improving insulin resistance, in hyperlipidemia.

Chu X, Liu L, Na L, Lu H, Li S, Li Y, Sun C.

Diabetes. 2013 Feb;62(2):561-71. 


10月10日 M.K

PPARβ/δ governs Wnt signaling and bone turnover.

Scholtysek C, Katzenbeisser J, Fu H, Uderhardt S, Ipseiz N, Stoll C, Zaiss MM, Stock M, Donhauser L, Böhm C, Kleyer A, Hess A, Engelke K, David JP, Djouad F, Tuckermann JP, Desvergne B, Schett G, Krönke G.

Nat Med. 2013 May;19(5):608-13.


10月7日 A.S

The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy.

Füllgrabe J, Lynch-Day MA, Heldring N, Li W, Struijk RB, Ma Q, Hermanson O, Rosenfeld MG, Klionsky DJ, Joseph B.

Nature. 2013 Aug 22;500(7463):468-71. 


10月3日 N.K

Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin.

Fujikawa T, Berglund ED, Patel VR, Ramadori G, Vianna CR, Vong L, Thorel F, Chera S, Herrera PL, Lowell BB, Elmquist JK, Baldi P, Coppari R.

Cell Metab. 2013 Sep 3;18(3):431-44.

 

9月19日 Y.O

Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat.

Carrieri C, Cimatti L, Biagioli M, Beugnet A, Zucchelli S, Fedele S, Pesce E, Ferrer I, Collavin L, Santoro C, Forrest AR, Carninci P, Biffo S, Stupka E, Gustincich S.

Nature. 2012 Nov 15;491(7424):454-7.


9月11日 A.S

MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion.

Soh J, Iqbal J, Queiroz J, Fernandez-Hernando C, Hussain MM.

Nat Med. 2013 Jul;19(7):892-900. 


9月2日 M.K

Osteoblast-Targeted suppression of PPARγ increases osteogenesis through activation of mTOR signaling.

Sun H, Kim JK, Mortensen R, Mutyaba LP, Hankenson KD, Krebsbach PH.

Stem Cells. 2013 Oct;31(10):2183-92.


8月29日 T.K

Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1stability.

Pajvani UB, Qiang L, Kangsamaksin T, Kitajewski J, Ginsberg HN, Accili D.

Nat Med. 2013 Aug;19(8):1054-60.


8月26日 K.O

Hepatic cannabinoid receptor type 1 mediates alcohol-induced regulation of bile acid enzyme genes expression via CREBH.

Chanda D, Kim YH, Li T, Misra J, Kim DK, Kim JR, Kwon J, Jeong WI, Ahn SH, Park TS, Koo SH, Chiang JY, Lee CH, Choi HS.

PLoS One. 2013 Jul 22;8(7):e68845.


8月20日 K.O

ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response.

Heijmans J, van Lidth de Jeude JF, Koo BK, Rosekrans SL, Wielenga MC, van de Wetering M, Ferrante M, Lee AS, Onderwater JJ, Paton JC, Paton AW, Mommaas AM, Kodach LL, Hardwick JC, Hommes DW, Clevers H, Muncan V, van den Brink GR.

Cell Rep. 2013 Apr 25;3(4):1128-39. 


8月12日 K.T

Does vitamin D3 supplementation improve glucose homeostasis in overweight or obesewomen? A double-blind, randomized, placebo-controlled clinical trial.

Salehpour A, Shidfar F, Hosseinpanah F, Vafa M, Razaghi M, Amiri F.

Diabet Med. 2013 Dec;30(12):1477-81.


8月8日  K.O

Cold exposure promotes atherosclerotic plaque growth and instability via UCP1-dependent lipolysis.

Dong M, Yang X, Lim S, Cao Z, Honek J, Lu H, Zhang C, Seki T, Hosaka K, Wahlberg E, Yang J, Zhang L, Länne T, Sun B, Li X, Liu Y, Zhang Y, Cao Y.

Cell Metab. 2013 Jul 2;18(1):118-29.


8月1日 A.S

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome.

Yoshimoto S, Loo TM, Atarashi K, Kanda H, Sato S, Oyadomari S, Iwakura Y, Oshima K, Morita H, Hattori M, Honda K, Ishikawa Y, Hara E, Ohtani N.

Nature. 2013 Jul 4;499(7456):97-101


7月29日 H.O

Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity.

Asai M, Ramachandrappa S, Joachim M, Shen Y, Zhang R, Nuthalapati N, Ramanathan V, Strochlic DE, Ferket P, Linhart K, Ho C, Novoselova TV, Garg S, Ridderstråle M, Marcus C, Hirschhorn JN, Keogh JM, O'Rahilly S, Chan LF, Clark AJ, Farooqi IS, Majzoub JA.

Science. 2013 Jul 19;341(6143):275-8.


7月25日 Y.O

Myomaker is a membrane activator of myoblast fusion and muscle formation.

Millay DP, O'Rourke JR, Sutherland LB, Bezprozvannaya S, Shelton JM, Bassel-Duby R, Olson EN.

Nature. 2013 Jul 18;499(7458):301-5. 


7月11日 H.O

Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production.

Cao H, Sekiya M, Ertunc ME, Burak MF, Mayers JR, White A, Inouye K, Rickey LM, Ercal BC, Furuhashi M, Tuncman G, Hotamisligil GS.

Cell Metab. 2013 May 7;17(5):768-78. 


7月8日 Y.O

The role of autophagy in the pathogenesis of glycogen storage disease type II (GSDII).

Nascimbeni AC, Fanin M, Masiero E, Angelini C, Sandri M.

Cell Death Differ. 2012 Oct;19(10):1698-708. 


7月1日 K.I

Ependymal cells of chordate larvae are stem-like cells that form the adult nervous system.

Horie T, Shinki R, Ogura Y, Kusakabe TG, Satoh N, Sasakura Y.

Nature. 2011 Jan 27;469(7331):525-8. 


6月27日 T.I

Diet1 Functions in the FGF15/19 Enterohepatic Signaling Axis to Modulate Bile Acid and Lipid Levels.

Vergnes L, Lee JM, Chin RG, Auwerx J, Reue K.

Cell Metab. 2013 Jun 4;17(6):916-28.


6月17日 Y.O

RNA mimics of green fluorescent protein.

Paige JS, Wu KY, Jaffrey SR.

Science. 2011 Jul 29;333(6042):642-6.


6月13日 K.I

Glucagon-induced acetylation of Foxa2 regulates hepatic lipid metabolism.

von Meyenn F, Porstmann T, Gasser E, Selevsek N, Schmidt A, Aebersold R, Stoffel M.

Cell Metab. 2013 Mar 5;17(3):436-47. 


6月10日 K.O

The Rab8 GTPase regulates apical protein localization in intestinal cells.

Sato T, Mushiake S, Kato Y, Sato K, Sato M, Takeda N, Ozono K, Miki K, Kubo Y, Tsuji A, Harada R, Harada A.

Nature. 2007 Jul 19;448(7151):366-9. 


6月5日 T.Y

Myocardial infarction accelerates atherosclerosis.

Dutta P, Courties G, Wei Y, Leuschner F, Gorbatov R, Robbins CS, Iwamoto Y, Thompson B, Carlson AL, Heidt T, Majmudar MD, Lasitschka F, Etzrodt M, Waterman P, Waring MT, Chicoine AT, van der Laan AM, Niessen HW, Piek JJ, Rubin BB, Butany J, Stone JR, Katus HA, Murphy SA, Morrow DA, Sabatine MS, Vinegoni C, Moskowitz MA, Pittet MJ, Libby P, Lin CP, Swirski FK, Weissleder R, Nahrendorf M.

Nature. 2012 Jul 19;487(7407):325-9. 


6月3日 K.O

Estrogen reduces lipid content in the liver exclusively from membrane receptor signaling.

Pedram A, Razandi M, O'Mahony F, Harvey H, Harvey BJ, Levin ER.

Sci Signal. 2013 May 21;6(276):ra36.

 

5月27日 T.I

High-fat diet determines the composition of the murine gut microbiome independently of obesity.

Hildebrandt MA, Hoffmann C, Sherrill-Mix SA, Keilbaugh SA, Hamady M, Chen YY, Knight R, Ahima RS, Bushman F, Wu GD.

Gastroenterology. 2009 Nov;137(5):1716-24.e1-2. 


5月9日 A.S

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop.

Settembre C, De Cegli R, Mansueto G, Saha PK, Vetrini F, Visvikis O, Huynh T, Carissimo A, Palmer D, Jürgen Klisch T, Wollenberg AC, Di Bernardo D, Chan L, Irazoqui JE, Ballabio A.

Nature Cell Biology.  2013 Apr 21.

 

5月2日 A.S

Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance.

Liew CW, Boucher J, Cheong JK, Vernochet C, Koh HJ, Mallol C, Townsend K, Langin D, Kawamori D, Hu J, Tseng YH, Hellerstein MK, Farmer SR, Goodyear L, Doria A, Blüher M, Hsu SI, Kulkarni RN.

Nat Med. 2013 Feb;19(2):217-26. 


4月22日  T.K

Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis.

Koeth RA, Wang Z, Levison BS, Buffa JA, Org E, Sheehy BT, Britt EB, Fu X, Wu Y, Li L, Smith JD, DiDonato JA, Chen J, Li H, Wu GD, Lewis JD, Warrier M, Brown JM, Krauss RM, Tang WH, Bushman FD, Lusis AJ, Hazen SL.

Nat Med. 2013 May;19(5):576-85.


4月18日 N.K

Succinate is an inflammatory signal that induces IL-1β through HIF-1α.

Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LA.

Nature. 2013 Apr 11;496(7444):238-42.

 

4月15日 A.S

CITED2 links hormonal signaling to PGC-1α acetylation in the regulation of gluconeogenesis.

Sakai M, Matsumoto M, Tujimura T, Yongheng C, Noguchi T, Inagaki K, Inoue H, Hosooka T, Takazawa K, Kido Y, Yasuda K, Hiramatsu R, Matsuki Y, Kasuga M.

Nat Med. 2012 Mar 18;18(4):612-7. 


4月11日 H.O

Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages.

Satoh T, Kidoya H, Naito H, Yamamoto M, Takemura N, Nakagawa K, Yoshioka Y, Morii E, Takakura N, Takeuchi O, Akira S.

Nature. 2013 Mar 28;495(7442):524-8.

 

4月4日 K.O

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.

Huch M, Dorrell C, Boj SF, van Es JH, Li VS, van de Wetering M, Sato T, Hamer K, Sasaki N, Finegold MJ, Haft A, Vries RG, Grompe M, Clevers H.

Nature. 2013 Feb 14;494(7436):247-50.


3月28日 K.O

ER stress induces hepatic steatosis via increased expression of the hepatic VLDL receptor.

Jo H, Choe SS, Shin KC, Jang H, Lee JH, Seong JK, Back SH, Kim JB.

Hepatology. 2012 Nov 13. 
 

3月21日 Y.O

Duration of rapamycin treatment has differential effects on metabolism in mice.

Fang Y, Westbrook R, Hill C, Boparai RK, Arum O, Spong A, Wang F, Javors MA, Chen J, Sun LY, Bartke A.

Cell Metab. 2013 Mar 5;17(3):456-62.


3月11日 Y.O

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure.

Oka T, Hikoso S, Yamaguchi O, Taneike M, Takeda T, Tamai T, Oyabu J, Murakawa T, Nakayama H, Nishida K, Akira S, Yamamoto A, Komuro I, Otsu K.

Nature. 2012 May 10;485(7397):251-5.


3月4日 T.K

Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo.

Kir S, Zhang Y, Gerard RD, Kliewer SA, Mangelsdorf DJ.

J Biol Chem. 2012 Nov 30;287(49):41334-41


2月27日 Y.N

Liver-Derived Systemic Factors Drive β Cell Hyperplasia in Insulin-Resistant States.

El Ouaamari A, Kawamori D, Dirice E, Liew CW, Shadrach JL, Hu J, Katsuta H, Hollister-Lock J, Qian WJ, Wagers AJ, Kulkarni RN.

Cell Rep. 2013 Feb 21;3(2):401-10.


2月20日 A.N

Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders.

Song R, Peng W, Zhang Y, Lv F, Wu HK, Guo J, Cao Y, Pi Y, Zhang X, Jin L, Zhang M, Jiang P, Liu F, Meng S, Zhang X, Jiang P, Cao CM, Xiao RP.

Nature. 2013 Feb 21;494(7437):375-9. 


2月18日 A.N

Cardiac-specific deletion of acetyl CoA carboxylase 2 prevents metabolic remodeling during pressure-overload hypertrophy.

Kolwicz SC Jr, Olson DP, Marney LC, Garcia-Menendez L, Synovec RE, Tian R.

Circ Res. 2012 Aug 31;111(6):728-38.



1月31日 K.S

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis.

Knobloch M, Braun SM, Zurkirchen L, von Schoultz C, Zamboni N, Araúzo-Bravo MJ, Kovacs WJ, Karalay O, Suter U, Machado RA, Roccio M, Lutolf MP, Semenkovich CF, Jessberger S.

Nature. 2013 Jan 10;493(7431):226-30.



1月24日 A.S

Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions.

Habegger KM, Stemmer K, Cheng C, Müller TD, Heppner KM, Ottaway N, Holland J, Hembree JL, Smiley D, Gelfanov V, Krishna R, Arafat AM, Konkar A, Belli S, Kapps M, Woods SC, Hofmann SM, D'Alessio D, Pfluger PT, Perez-Tilve D, Seeley RJ, Konishi M, Itoh N, Kharitonenkov A, Spranger J, Dimarchi RD, Tschöp MH.

Diabetes. 2013 Jan 10. 


1月11日 N.K

A fructose receptor functions as a nutrient sensor in the Drosophila brain.

Miyamoto T, Slone J, Song X, Amrein H.

Cell. 2012 Nov 21;151(5):1113-25.


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