2012年

12月27日 T.K

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine.

Kim KH, Jeong YT, Oh H, Kim SH, Cho JM, Kim YN, Kim SS, Kim do H, Hur KY, Kim HK, Ko T, Han J, Kim HL, Kim J, Back SH, Komatsu M, Chen H, Chan DC, Konishi M, Itoh N, Choi CS, Lee MS.

Nat Med. 2013 Jan;19(1):83-92.

 

12月12日 K.O

Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance.

Vernochet C, Mourier A, Bezy O, Macotela Y, Boucher J, Rardin MJ, An D, Lee KY, Ilkayeva OR, Zingaretti CM, Emanuelli B, Smyth G, Cinti S, Newgard CB, Gibson BW, Larsson NG, Kahn CR.

Cell Metab. 2012 Dec 5;16(6):765-76.



12月5日 H.O

Gut-derived serotonin is a multifunctional determinant to fasting adaptation.]

Sumara G, Sumara O, Kim JK, Karsenty G.

Cell Metab. 2012 Nov 7;16(5):588-600.


11月19日 K.S

Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists.

Solt LA, Wang Y, Banerjee S, Hughes T, Kojetin DJ, Lundasen T, Shin Y, Liu J, Cameron MD, Noel R, Yoo SH, Takahashi JS, Butler AA, Kamenecka TM, Burris TP.

Nature. 2012 Mar 29;485(7396):62-8. 


11月8日 Y.N

MitoNEET-driven alterations in adipocyte mitochondrial activity reveal a crucial adaptive process that preserves insulin sensitivity in obesity.

Kusminski CM, Holland WL, Sun K, Park J, Spurgin SB, Lin Y, Askew GR, Simcox JA, McClain DA, Li C, Scherer PE.

Nat Med. 2012 Oct;18(10):1539-49. 


11月5日 N.K

Rapid induction of inflammatory lipid mediators by the inflammasome in vivo.

von Moltke J, Trinidad NJ, Moayeri M, Kintzer AF, Wang SB, van Rooijen N, Brown CR, Krantz BA, Leppla SH, Gronert K, Vance RE.

Nature. 2012 Oct 4;490(7418):107-11.

 

11月1日 A.N

Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals.

Bal NC, Maurya SK, Sopariwala DH, Sahoo SK, Gupta SC, Shaikh SA, Pant M, Rowland LA, Goonasekera SA, Molkentin JD, Periasamy M.

Nat Med. 2012 Sep 9;18(10):1575-9.

 

10月29日 Y.N

Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes.

Morán I, Akerman I, van de Bunt M, Xie R, Benazra M, Nammo T, Arnes L, Nakić N, García-Hurtado J, Rodríguez-Seguí S, Pasquali L, Sauty-Colace C, Beucher A, Scharfmann R, van Arensbergen J, Johnson PR, Berry A, Lee C, Harkins T, Gmyr V, Pattou F, Kerr-Conte J, Piemonti L, Berney T, Hanley N, Gloyn AL, Sussel L, Langman L, Brayman KL, Sander M, McCarthy MI, Ravassard P, Ferrer J.

Cell Metab. 2012 Oct 3;16(4):435-48.

 

10月25日 H.T

TAp63 Is a Master Transcriptional Regulator of Lipid and Glucose Metabolism.

Su X, Gi YJ, Chakravarti D, Chan IL, Zhang A, Xia X, Tsai KY, Flores ER.

Cell Metab. 2012 Oct 3;16(4):511-25.

 

10月22日 A.S

Humans can learn new information during sleep.

Arzi A, Shedlesky L, Ben-Shaul M, Nasser K, Oksenberg A, Hairston IS, Sobel N.

Nat Neurosci. 2012 Oct;15(10):1460-5.

 

10月17日 K.S

Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet.

Hatori M, Vollmers C, Zarrinpar A, DiTacchio L, Bushong EA, Gill S, Leblanc M, Chaix A, Joens M, Fitzpatrick JA, Ellisman MH, Panda S.

Cell Metab. 2012 Jun 6;15(6):848-60.

 

10月4日 Y.T

Multigenerational epigenetic adaptation of the hepatic wound-healing response.

Zeybel M, Hardy T, Wong YK, Mathers JC, Fox CR, Gackowska A, Oakley F, Burt AD, Wilson CL, Anstee QM, Barter MJ, Masson S, Elsharkawy AM, Mann DA, Mann J.

Nat Med. 2012 Sep;18(9):1369-77.

 

9月24日 A.S

High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction.

Chalkiadaki A, Guarente L.

Cell Metab. 2012 Aug 8;16(2):180-8.

 

9月13日 A.S

βKlotho is required for fibroblast growth factor 21 effects on growth and metabolism.

Ding X, Boney-Montoya J, Owen BM, Bookout AL, Coate KC, Mangelsdorf DJ, Kliewer SA.

Cell Metab. 2012 Sep 5;16(3):387-93.


9月10日

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study.

Mattison JA, Roth GS, Beasley TM, Tilmont EM, Handy AM, Herbert RL, Longo DL, Allison DB, Young JE, Bryant M, Barnard D, Ward WF, Qi W, Ingram DK, de Cabo R.

Nature. 2012 Sep 13;489(7415):318-21. 


 

9月6日 N.K

p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake.

Dagon Y, Hur E, Zheng B, Wellenstein K, Cantley LC, Kahn BB.

Cell Metab. 2012 Jul 3;16(1):104-12.

 

  

9月3日 A.N

Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation.

Haldar SM, Jeyaraj D, Anand P, Zhu H, Lu Y, Prosdocimo DA, Eapen B, Kawanami D, Okutsu M, Brotto L, Fujioka H, Kerner J, Rosca MG, McGuinness OP, Snow RJ, Russell AP, Gerber AN, Bai X, Yan Z, Nosek TM, Brotto M, Hoppel CL, Jain MK.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6739-44.  

 

 

8月27日 H.T

Nuclear receptor PPARγ-regulated monoacylglycerol O-acyltransferase 1 (MGAT1) expression is responsible for the lipid accumulation in diet-induced hepatic steatosis.

Lee YJ, Ko EH, Kim JE, Kim E, Lee H, Choi H, Yu JH, Kim HJ, Seong JK, Kim KS, Kim JW.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13656-61. 

 

 

8月23日 K.O

ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation.

Hashimoto T, Perlot T, Rehman A, Trichereau J, Ishiguro H, Paolino M, Sigl V, Hanada T, Hanada R, Lipinski S, Wild B, Camargo SM, Singer D, Richter A, Kuba K, Fukamizu A, Schreiber S, Clevers H, Verrey F, Rosenstiel P, Penninger JM.

Nature. 2012 Jul 25;487(7408):477-81. 

 

 

8月20日 T.K

A map of the cis-regulatory sequences in the mouse genome.

Shen Y, Yue F, McCleary DF, Ye Z, Edsall L, Kuan S, Wagner U, Dixon J, Lee L, Lobanenkov VV, Ren B.

Nature. 2012 Aug 2;488(7409):116-20.

 

 

8月2日 Y.O

Le Guezennec X, Brichkina A, Huang F, Kostromina E, Han W, Bulavin DV.Cell Metab. 2012 Jul 3;16(1):68-80.

 

7月30日

Hyperresponsivity to low-dose endotoxin during progression to nonalcoholic steatohepatitis is regulated by leptin-mediated signaling.

Imajo K, Fujita K, Yoneda M, Nozaki Y, Ogawa Y, Shinohara Y, Kato S, Mawatari H, Shibata W, Kitani H, Ikejima K, Kirikoshi H, Nakajima N, Saito S, Maeyama S, Watanabe S, Wada K, Nakajima A.

Cell Metab. 2012 Jul 3;16(1):44-54.

 

 

7月23日 K.O

Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human.

Wu J, Boström P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerbäck S, Schrauwen P, Spiegelman BM.

Cell. 2012 Jul 20;150(2):366-76.

 

7月12日 K.I

mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.

Yilmaz ÖH, Katajisto P, Lamming DW, Gültekin Y, Bauer-Rowe KE, Sengupta S, Birsoy K, Dursun A, Yilmaz VO, Selig M, Nielsen GP, Mino-Kenudson M, Zukerberg LR, Bhan AK, Deshpande V, Sabatini DM.

Nature. 2012 Jun 28;486(7404):490-5.

 

 

7月9日 H.O

Pten regulates neuronal arborization and social interaction in mice.

Kwon CH, Luikart BW, Powell CM, Zhou J, Matheny SA, Zhang W, Li Y, Baker SJ, Parada LF.

Neuron. 2006 May 4;50(3):377-88. 

 

 

 

7月4日 M.N

Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes.

Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I.

Cell. 2012 Jun 8;149(6):1298-313.

 

 

 

6月28日 Y.N

Adenosine signaling promotes regeneration of pancreatic β cells in vivo.

Andersson O, Adams BA, Yoo D, Ellis GC, Gut P, Anderson RM, German MS, Stainier DY.

Cell Metab. 2012 Jun 6;15(6):885-94.

 

 

 

6月25日 M.N

poE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models.

Cramer PE, Cirrito JR, Wesson DW, Lee CY, Karlo JC, Zinn AE, Casali BT, Restivo JL, Goebel WD, James MJ, Brunden KR, Wilson DA, Landreth GE.

Science. 2012 Mar 23;335(6075):1503-6.

 


6月20日 A.N

PPARα-Sirt1 complex mediates cardiac hypertrophy and failure through suppression of the ERR transcriptional pathway.

Oka S, Alcendor R, Zhai P, Park JY, Shao D, Cho J, Yamamoto T, Tian B, Sadoshima J.

Cell Metab. 2011 Nov 2;14(5):598-611.

 

 

6月18日 H.T

CITED2 links hormonal signaling to PGC-1α acetylation in the regulation of gluconeogenesis.

Sakai M, Matsumoto M, Tujimura T, Yongheng C, Noguchi T, Inagaki K, Inoue H, Hosooka T, Takazawa K, Kido Y, Yasuda K, Hiramatsu R, Matsuki Y, Kasuga M.

Nat Med. 2012 Mar 18;18(4):612-7.

 

 

6月13日 H.T

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration.

Sun Z, Miller RA, Patel RT, Chen J, Dhir R, Wang H, Zhang D, Graham MJ, Unterman TG, Shulman GI, Sztalryd C, Bennett MJ, Ahima RS, Birnbaum MJ, Lazar MA.

Nat Med. 2012 Jun;18(6):934-42.

 

 

6月11日 K.O

Interconversion between intestinal stem cell populations in distinct niches.

Takeda N, Jain R, LeBoeuf MR, Wang Q, Lu MM, Epstein JA.

Science. 2011 Dec 9;334(6061):1420-4.

 

6月7日 Y.T

Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.

Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR.

Cell. 2012 Jun 22;149(7):1635-46.


6月4日 Y.N

Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation.

Eguchi K, Manabe I, Oishi-Tanaka Y, Ohsugi M, Kono N, Ogata F, Yagi N, Ohto U, Kimoto M, Miyake K, Tobe K, Arai H, Kadowaki T, Nagai R.

Cell Metab. 2012 Apr 4;15(4):518-33.



5月28日 N.K

A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene expression by polyunsaturated fatty acids.

Yahagi N, Shimano H, Hasty AH, Amemiya-Kudo M, Okazaki H, Tamura Y, Iizuka Y, Shionoiri F, Ohashi K, Osuga J, Harada K, Gotoda T, Nagai R, Ishibashi S, Yamada N.

J Biol Chem. 1999 Dec 10;274(50):35840-4.

Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1 through proteolytic processing and autoloop regulatory circuit.

Takeuchi Y, Yahagi N, Izumida Y, Nishi M, Kubota M, Teraoka Y, Yamamoto T, Matsuzaka T, Nakagawa Y, Sekiya M, Iizuka Y, Ohashi K, Osuga J, Gotoda T, Ishibashi S, Itaka K, Kataoka K, Nagai R, Yamada N, Kadowaki T, Shimano H.

J Biol Chem. 2010 Apr 9;285(15):11681-91.

 

 


5月23日 A.S

Dynamic O-GlcNAc modification regulates CREB-mediated gene expression and memory formation.

Rexach JE, Clark PM, Mason DE, Neve RL, Peters EC, Hsieh-Wilson LC.

Nat Chem Biol. 2012 Jan 22;8(3):253-61.


5月16日 N.K

SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive.

Libert S, Pointer K, Bell EL, Das A, Cohen DE, Asara JM, Kapur K, Bergmann S, Preisig M, Otowa T, Kendler KS, Chen X, Hettema JM, van den Oord EJ, Rubio JP, Guarente L.

Cell. 2011 Dec 23;147(7):1459-72.

 

 

5月10日  T.K

A Cardiac MicroRNA Governs Systemic Energy Homeostasis by Regulation of MED13.

Grueter CE, van Rooij E, Johnson BA, Deleon SM, Sutherland LB, Qi X, Gautron L, Elmquist JK, Bassel-Duby R, Olson EN.

Cell. 2012 Apr 27;149(3):671-83.

 

 

 

4月18日  K.O

Generation of functional insulin-producing cells in the gut by Foxo1 ablation.

Talchai C, Xuan S, Kitamura T, Depinho RA, Accili D.

Nat Genet. 2012 Mar 11;44(4):406-12.

 

 

 

4月16日 N.K

Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.

Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, Inoue N, Ishikawa M, Okada S, Ishigaki N, Iwasaki H, Iwasaki Y, Karasawa T, Kumadaki S, Matsui T, Sekiya M, Ohashi K, Hasty AH, Nakagawa Y, Takahashi A, Suzuki H, Yatoh S, Sone H, Toyoshima H, Osuga J, Yamada N.

Nat Med. 2007 Oct;13(10):1193-202.

 

 

4月12日 K.I

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.

Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA.

Science. 2012 Mar 30;335(6076):1638-43.

 

 

4月9日 K.S

TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates diabetes.

Nakagawa Y, Shimano H, Yoshikawa T, Ide T, Tamura M, Furusawa M, Yamamoto T, Inoue N, Matsuzaka T, Takahashi A, Hasty AH, Suzuki H, Sone H, Toyoshima H, Yahagi N, Yamada N.

Nat Med. 2006 Jan;12(1):107-13.

 

 

3月29日 Y.N

FTY720 normalizes hyperglycemia by stimulating β-cell in vivo regeneration in db/db mice through regulation of cyclin D3 and p57(KIP2).

Zhao Z, Choi J, Zhao C, Ma ZA.

J Biol Chem. 2012 Feb 17;287(8):5562-73. 


3月22日 A.N

NCoR1 is a conserved physiological modulator of muscle mass and oxidative function.

Yamamoto H, Williams EG, Mouchiroud L, Cantó C, Fan W, Downes M, Héligon C, Barish GD, Desvergne B, Evans RM, Schoonjans K, Auwerx J.

Cell. 2011 Nov 11;147(4):827-39.

 

 

3月14日 H.T

Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones.

Dutchak PA, Katafuchi T, Bookout AL, Choi JH, Yu RT, Mangelsdorf DJ, Kliewer SA.

Cell. 2012 Feb 3;148(3):556-67.

 

 

2月29日 Y.T 

The sirtuin SIRT6 regulates lifespan in male mice.

Kanfi Y, Naiman S, Amir G, Peshti V, Zinman G, Nahum L, Bar-Joseph Z, Cohen HY.

Nature. 2012 Feb 22;483(7388):218-21.

 

 

2月8日  A.S

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.

Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM.

Nature. 2012 Jan 11;481(7382):463-8.

 

 

2月6日 Y.N

Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance.

Maris M, Overbergh L, Gysemans C, Waget A, Cardozo AK, Verdrengh E, Cunha JP, Gotoh T, Cnop M, Eizirik DL, Burcelin R, Mathieu C.

Diabetologia. 2012 Apr;55(4):1167-78.


1月30日 R.M

TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading. 

Pols TW, Nomura M, Harach T, Lo Sasso G, Oosterveer MH, Thomas C, Rizzo G, Gioiello A, Adorini L, Pellicciari R, Auwerx J, Schoonjans K. 

Cell Metab. 2011 Dec 7;14(6):747-57. 


1月26日 K.K 

Srf-dependent paracrine signals produced by myofibers control satellite cell-mediated skeletal muscle hypertrophy.

Guerci A, Lahoute C, Hébrard S, Collard L, Graindorge D, Favier M, Cagnard N, Batonnet-Pichon S, Précigout G, Garcia L, Tuil D, Daegelen D, Sotiropoulos A.

Cell Metab. 2012 Jan 4;15(1):25-37.


 

1月19日 T.K

Impaired generation of 12-hydroxylated bile acids links hepatic insulin signaling with dyslipidemia.

Haeusler RA, Pratt-Hyatt M, Welch CL, Klaassen CD, Accili D.

Cell Metab. 2012 Jan 4;15(1):65-74.



1月16日 N.K 

Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c. 

Wan M, Leavens KF, Saleh D, Easton RM, Guertin DA, Peterson TR, Kaestner KH, Sabatini DM, Birnbaum MJ. 

Cell Metab. 2011 Oct 5;14(4):516-27. 



1月12日 N.K

A role for neuronal cAMP responsive-element binding (CREB)-1 in brain responses to calorie restriction.

Fusco S, Ripoli C, Podda MV, Ranieri SC, Leone L, Toietta G, McBurney MW, Schütz G, Riccio A, Grassi C, Galeotti T, Pani G.

Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):621-6.


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  •  0119 T.K.docx (122KB)   1月19日 T.K
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  •  0112 N.K.docx (19KB)   1月12日 N.K
    Proc Natl Acad Sci U S A. 2012 Jan 10;109(2):621-6.